UNIQUE DIFFERENTIATOR
FULL-LENGTHMEMBRANE PROTEINS
Proteins are inserted directly into native membranes during expression through an active biological translocation pathway. This allows full-length membrane proteins to fold, orient, and assemble correctly from the start.
ALiCE®
WHY THIS MATTERS
- Fragments are incomplete: Protein fragments lack native structure and often misrepresent biological function.
- Post-insertion carries risk: Reconstituting proteins into membranes after expression can lead to improper orientation or incomplete integration.
- Detergents disrupt structure: Detergent-based isolation destabilizes membrane complexes and alters protein behavior.
ALiCE® avoids these limitations.
WHAT ALiCE®ENABLES
- Full-length membrane proteins, including GPCRs, ion channels, and receptor kinases.
- Native membrane insertion during synthesis, not after.
- Isolation of intact membrane-protein complexes without detergents.
This produces proteins that behave more like they do in living systems — and provides data you can trust.
If your protein is difficult, toxic, or previously failed, ALiCE® is built for exactly that challenge.
